This encounter between West Ham United and Tottenham Hotspur is poised to be a tightly contested affair, typical of a London derby. Our analysis favors an away victory for Tottenham, predicated on their historical dominance in this fixture and their ability to cope with significant injuries. The odds reflect this, positioning Spurs as the favorites. Key injuries to Tottenham's creative hub, with both James Maddison and Dejan Kulusevski sidelined, will undoubtedly impact their attacking fluidity. However, the presence of Son Heung-min and Richarlison ensures they still carry a potent goal threat. West Ham's prospects are hampered by their own injury concerns, particularly the potential absence of Emerson, which would weaken their defensive structure. Their recent form has been a mixed bag, showing flashes of capability but also significant defensive vulnerabilities, as seen in their heavy defeat to Chelsea. For the Hammers to succeed, they will need to be defensively disciplined and exceptionally clinical on the counter-attack, with James Ward-Prowse's set-piece delivery being a key weapon. The head-to-head record suggests goals are likely, with a majority of recent meetings seeing both teams score. This aligns with our high confidence in the 'Both Teams to Score' market. Given the attacking talent on display, even with the absentees, a prediction of over 2.5 total goals also appears statistically sound. While a narrow 2-1 victory for Spurs is our specific scoreline prediction, the unpredictable nature of this derby means a draw or even a West Ham win are outcomes that cannot be entirely discounted.